PGS-IN-1 (Synonyms: KME-4)

Cat. No.: HY-101587 Purity: 99.51%: FAQs
Data Sheet SDS COA Handling Instructions

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PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC₅₀ of 0.28 μM; also inhibits 5-lipoxygenase with an IC₅₀ of 1.05 μM.

For research use only. We do not sell to patients.

PGS-IN-1 Chemical Structure

CAS No. : 102271-49-8

Size	Price	Stock	Quantity
5 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 470	In-stock	Estimated Time of Arrival: December 31
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Description

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC₅₀ of 0.28 μM; also inhibits 5-lipoxygenase with an IC₅₀ of 1.05 μM.

IC₅₀ & Target

5-Lipoxygenase

1.05 μM (IC₅₀)

In Vitro

The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC₅₀=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC₅₀=1.05 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.41

Formula

C₁₉H₂₆O₃

CAS No.

102271-49-8

Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.51%

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Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) HNMR (185 KB) LCMS (124 KB)

Handling Instructions (2659 KB)

References

[1]. Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9. [Content Brief]

Kinase Assay ^[1]	PGS-IN-1 is dissolved in ethanol and the final concentration of ethanol is kept at 2% in each assay. The reaction mixture includes reaction buffer, enzyme (20 μg protein), and PGS-IN-1 in a total volume of 0.2 mL. The mixture is incubated for 15 min at 37°C with shaking and terminated by the addition of 2.5 mL ethyl acetate and 25 μL 1 N formic acid^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Rats: PGS-IN-1 is administered orally to groups of 4-6 male Wistar rats weighting 160-220 g. One hour later, 1 % carrageenin in 0.9 % NaCl is injected subcutaneously into a hind paw. Paw volumes are measured 5 h after the injection^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9. [Content Brief]

PGS-IN-1 Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGS-IN-1102271-49-8KME-4KME4KME 4PGE synthaseLipoxygenaseProstaglandin E synthaseLOXInhibitorinhibitorinhibit

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